Mithocodria

During my AD studies, I suddenly found myself in a world of mithocondria, reactive oxygen species, electron transport chains…

But how is difficult to remember argument studied long time ago…!

In You-Tube there are several videos that provide an excellent way to remember everything in a few minutes

Act 1: Origin of mithocondria

Act 2: function of mithocondria

Act 3: welcome into another world

Happy holidays!

Merry Christimas to everyone!

Clinical sciences

In this period I’m bound to study for some specialization exams and I have to review some arguments… 

I found a very original website, which provides memorizing strategies and helps in learning of clinical and basic sciences in an enjoyable, funny and intellectually stimulating manner.

So learn and enjoy yourselves with MedMemoWeb

Brain Atlases

Nuclear medicine is approaching to neurology.

Here are some atlases of neuroanatomy which could help in nuclear medicine practice.

http://www.med.harvard.edu/AANLIB/home.html

a whole brain atlas from Harvard University, in which we can find atlases of normal brain, and also of cerebrovascular, neoplastic, degenerative and inflammatory diseases.

http://www.neuroanatomy.wisc.edu/neuroweb.html

in which there are some interesting neuroscience videos.

http://www.msu.edu/~brains/

From Michigan State University, atlases of human brain and of other animals (Brain Biodiversity Bank).

Herpetic limbic encephalitis

Besides causing the common oral lesions, HSV-1 is associated with encephalitis and is the more common cause of adult encephalitis. Pathophysiology of this encephalitis is poorly understood in humans. Animal models suggest that the virus enters the CNS via peripheral nerves. Virus-induced apoptosis may play a role in the molecular pathogenesis of herpes simplex encephalitis (HSE).
The encephalitis affects the temporal lobes of the brain in most cases. Wasay et al (Eur J Neurol 2005;12(6):475-9) report temporal lobe involvement in 60% of patients. Fifty-five percent of patients demonstrated temporal and extratemporal pathology, and 15% of patients demonstrated extratemporal pathology exclusively.
Generally, patients may have a prodrome of malaise, fever, headache and nausea. These are followed by acute or subacute onset of an encephalopathy whose symptoms include lethargy, confusion and delirium. Headaches, seizures, aphasia and other focal deficits also may occur. On neurological examinations, global and focal neurologic findings include encephalopathy, delirium, aphasia, cranial nerve deficits and hemiparesis. Meningeal signs may be present. Unusual presentations occur:
- Ku et al (Pediatr Neurol 1996;15(2):169-71) discussed the unique presentation of HSE in a bilingual patient, who developed global aphasia for 1 language (his most recently learned language) but retained most of his birth language ability.
- McGrath et al (Neurology 1997;49(2):494-7) reported on 4 patients with confirmed HSE, each with an anterior opercular syndrome. The syndrome (ie, paralysis of the masticatory, facial, pharyngeal, and lingual muscles) occurred as the primary manifestation of HSE in 2 patients and as part of the encephalitis picture in the other 2 patients. The authors suggested that unique presentations, such as the anterior opercular syndrome, should alert the clinician to the possibility of HSE.
CT scan or MRI scan show abnormal mass or abnormal signal at temporal lobe.
CASE REPORT
A 58-year-old man, after a brief period of malaise, developed disorientation, difficulty with short-term memory and then aphasia and epileptic seizures. He was hospitalized and was started on antiepileptic therapy. He was also treated with acyclovir for presumed herpes encephalitis, which was confirmed by the MRI scan, that demonstrated altered signal in left medial temporal lobe. Two weeks later, patient’s symptoms were disappeared and he was dismissed from the hospital.
18F-FDG PET scans of this patient are shown below.

18F-FDG PET scan shows an area of increased uptake of FDG in the left hippocampus.

The glucose metabolism in the left hippocampus is significantly greater than in the right hippocampus.

So, this is the case report..

If anyone has suggestions or comments….

Case Reports

Discussions about clinical cases are so important to improve our medical experience!

Recently I heard talking about the Journal of Radiology Case Reports (http://www.radiologycases.com/index.php/radiologycases/index), a new open-access radiology journal which will be soon indexed in Medline/Pubmed. The articles are in multiple formats (HTML, PDF and also in an interactive one).

So, let’s take out our most interesting cases…

LHC

The LHC (Large Hadron Collider) will start his hard job on September 10th. In the meanwhile…Let’s RAP!

Visit this URL and dance with us… LHC Rap

Hello world!

Everything began when a professor told us about a new way of teaching and proposed us a “formative experiment”…

He asked us to “make something”, and to “go somewhere”, and to “loose ourselves”… He told us about WEB 2.0 and social networking.

So, here we are… 

A group of training doctors in nuclear medicine, who decided to grow up and to try to learn more…

We want to take part of this World and, why not, to contribute in our own small way.

 

 

 

 

Welcome on board Motard78!

My brakes are good but nothing can stop me…

How do I insert my avatar in the author’s list?